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Blood transfusion - 17th century (?)
"Anthropographia" (?) showing blood transfusion between man and sheep; ascribed to J. G. Riva (fl 1618) author of 'De triplici infusionis sanguinis experimento'
Iconographic Collections

First Blood Transfusion: A History

The world’s first experiments with blood transfusion occurred in the mid-1660s in England. The procedure, carried out between dogs, was gruesome.